Reactome | Alkalization of the phagosomal lumen by NOX2

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Alkalization of the phagosomal lumen by NOX2 Show undefined attributes

catalystActivity	[CatalystActivity:10681363] superoxide-generating NAD(P)H oxidase activity of NOX2 complex [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:263698] phagolysosome [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10681365
displayName	Alkalization of the phagosomal lumen by NOX2
eventOf	[Pathway:R-XTR-1236973] Cross-presentation of particulate exogenous antigens (phagosomes) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1236967] Alkalization of the phagosomal lumen by NOX2 - Homo sapiens
input	[SimpleEntity:R-ALL-2000347] NADPH [phagolysosome] 2 × [SimpleEntity:R-ALL-1236709] O2 [phagolysosome]
isInDisease	false
isInferred	true
maxDepth	1
name	Alkalization of the phagosomal lumen by NOX2
output	[SimpleEntity:R-ALL-2000349] H+ [phagolysosome] [SimpleEntity:R-ALL-2000348] NADP+ [phagolysosome] 2 × [SimpleEntity:R-ALL-2000345] O2.- [phagolysosome]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1236967
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1236973] Cross-presentation of particulate exogenous antigens (phagosomes)
(inferredTo)	[Reaction:R-HSA-1236967] Alkalization of the phagosomal lumen by NOX2

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