Reactome | p-Y185,Y187 MAPK1 dimer [nucleoplasm]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10664758] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
consumedByEvent	[Reaction:R-XTR-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10664757
displayName	p-Y185,Y187 MAPK1 dimer [nucleoplasm]
hasComponent	2 × [EntityWithAccessionedSequence:R-XTR-112354] phospho-p-T185,Y187-MAPK1 [nucleoplasm]
inDisease	false
inferredFrom	[DefinedSet:R-HSA-199878] p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-198701] p-T,Y MAPK dimers [nucleoplasm] - Homo sapiens [Complex:R-HSA-109856] p-Y185,Y187 MAPK1 dimer [nucleoplasm] - Homo sapiens
maxDepth	2
memberOf	[DefinedSet:R-XTR-5674341] p-T,Y MAPK monomers and dimers [nucleoplasm] - Xenopus tropicalis
name	p-Y185,Y187 MAPK1 dimer
positivelyRegulates	[PositiveRegulation:10721665] Positive regulation by 'p-Y185,Y187 MAPK1 dimer [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-XTR-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus - Xenopus tropicalis [BlackBoxEvent:R-XTR-9610166] p-T,Y MAPK dimers translocate to nucleus - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-109856
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[PositiveRegulation:10721665] Positive regulation by 'p-Y185,Y187 MAPK1 dimer [nucleoplasm]'
(output)	[BlackBoxEvent:R-XTR-9632910] ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus [BlackBoxEvent:R-XTR-9610166] p-T,Y MAPK dimers translocate to nucleus
(input)	[Reaction:R-XTR-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs)
(inferredTo)	[DefinedSet:R-HSA-199878] p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm] [DefinedSet:R-HSA-198701] p-T,Y MAPK dimers [nucleoplasm] [Complex:R-HSA-109856] p-Y185,Y187 MAPK1 dimer [nucleoplasm]
(physicalEntity)	[CatalystActivity:10664758] protein serine/threonine kinase activity of p-MAPK3/MAPK1/MAPK7 dimers [nucleoplasm]
(hasMember)	[DefinedSet:R-XTR-5674341] p-T,Y MAPK monomers and dimers [nucleoplasm]