Reactome | GGC-GBP2, GGC-GBP5 bind furin

Schema > Reaction > Entries

category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555134
displayName	GGC-GBP2, GGC-GBP5 bind furin
eventOf	[Pathway:R-SSC-9953170] GBP-mediated host defense - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9954252] GGC-GBP2, GGC-GBP5 bind furin - Homo sapiens
input	2 × [EntityWithAccessionedSequence:R-SSC-157049] FURIN [Golgi membrane] 2 × [DefinedSet:R-SSC-9954225] GGC-GBP2, GGC-GBP5 [cytosol] 2 × [SimpleEntity:R-ALL-29438] GTP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GGC-GBP2, GGC-GBP5 bind furin
output	[DefinedSet:R-SSC-9954204] FURIN:GGC-GBP5:GTP, FURIN:GGC-GBP2:GTP [Golgi membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9954252
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-9953170] GBP-mediated host defense
(inferredTo)	[Reaction:R-HSA-9954252] GGC-GBP2, GGC-GBP5 bind furin

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