Reactome | SRD5A3 reduces polyprenal to dolichal

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SRD5A3 reduces polyprenal to dolichal Show undefined attributes

catalystActivity	[CatalystActivity:10554415] polyprenal reductase activity of SRD5A3 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:5263266] cytoplasmic side of endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10554417
displayName	SRD5A3 reduces polyprenal to dolichal
eventOf	[Pathway:R-SSC-446199] Synthesis of dolichyl-phosphate - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9937340] DHRSX reduces dolichal to dolichol - Sus scrofa
inferredFrom	[Reaction:R-HSA-9937295] SRD5A3 reduces polyprenal to dolichal - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-9937308] pNAL [cytoplasmic side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SRD5A3 reduces polyprenal to dolichal a di-trans,poly-cis-polyprenal + NADPH + H(+) => a di-trans,poly-cis-dolichal + NADP(+)
output	[SimpleEntity:R-ALL-9937289] DCHAL [cytoplasmic side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-SSC-9937298] DHRSX oxidizes polyprenol to polyprenal - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9937295
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-446199] Synthesis of dolichyl-phosphate
(precedingEvent)	[Reaction:R-SSC-9937340] DHRSX reduces dolichal to dolichol
(inferredTo)	[Reaction:R-HSA-9937295] SRD5A3 reduces polyprenal to dolichal

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