Reactome | TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa

Schema > Reaction > Entries

TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10553945
displayName	TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa
eventOf	[Pathway:R-SSC-9769739] Regulation of clotting cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221428] negative regulation of blood coagulation, extrinsic pathway
inferredFrom	[Reaction:R-HSA-9931624] TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa - Homo sapiens
input	[Complex:R-SSC-9822516] TF:FVIIa:FXa [plasma membrane] [Complex:R-SSC-9931610] TFPI?:FV intermediate:PROS1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa TFPI?:FV intermediate:PROS1 + TF:FVIIa:FXa -> TFPI?:FV inremediate:PROS1:TF:FVIIa:FXa
output	[Complex:R-SSC-9931650] TFPI?:FV inremediate:PROS1:TF:FVIIa:FXa [plasma membrane]
precedingEvent	[Reaction:R-SSC-9822514] TF:FVIIa+FX -> TF:FVIIa:FXa + FX activation peptide (TF:F7a catalyst) - Sus scrofa [Reaction:R-SSC-9929060] TF:FVII:FXa ->TF:FVIIa:FXa (FXa catalyst) - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9931624
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-9931624] TFPI?:FV intermediate:PROS1 binds TF:FVIIa:FXa

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