Reactome | HK1 phosphorylates Mannose to Man6P

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HK1 phosphorylates Mannose to Man6P Show undefined attributes

catalystActivity	[CatalystActivity:10553251] mannokinase activity of HK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10553253
displayName	HK1 phosphorylates Mannose to Man6P
eventOf	[Pathway:R-SSC-446205] Synthesis of GDP-mannose - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-446201] PMM1,2 isomerise Man6P to Man1P - Sus scrofa
inferredFrom	[Reaction:R-HSA-9909159] HK1 phosphorylates Mannose to Man6P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-429579] Man [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HK1 phosphorylates Mannose to Man6P ATP + D-mannose => ADP + D-mannose 6-phosphate + H(+)
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-532562] Man6P [cytosol]
precedingEvent	[Reaction:R-SSC-429567] Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4 - Sus scrofa [Reaction:R-SSC-8876283] SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9909159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-446205] Synthesis of GDP-mannose
(precedingEvent)	[Reaction:R-SSC-446201] PMM1,2 isomerise Man6P to Man1P
(inferredTo)	[Reaction:R-HSA-9909159] HK1 phosphorylates Mannose to Man6P

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