Reactome | BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV

Schema > Reaction > Entries

BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV Show undefined attributes

catalystActivity	[CatalystActivity:10552658] oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor of BCKDH [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10552660
displayName	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV
eventOf	[Pathway:R-SSC-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9859163] DBT transfers BCAA to CoA - Sus scrofa
inferredFrom	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-70017] DBT [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [DefinedSet:R-ALL-508181] KIC, KMVA, KIV [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV 3-methyl-2-oxobutanoate + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) => CO2 + N(6)-((R)-S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-(dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [EntityWithAccessionedSequence:R-SSC-9859145] DBT [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-70723] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1] - Sus scrofa [Reaction:R-SSC-5693153] PPM1K dephosphorylates p-BCKDH - Sus scrofa [Reaction:R-SSC-9859172] DLD dimer dehydrogenates dihydrolipoyl - Sus scrofa [Reaction:R-SSC-70724] leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2] - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9859148
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9859138] BCKDH synthesizes BCAA-CoA from KIC, KMVA, KIV
(precedingEvent)	[Reaction:R-SSC-9859163] DBT transfers BCAA to CoA
(inferredTo)	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV

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