Reactome | Transcriptional and post-translational regulation of MITF-M expression and activity

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Transcriptional and post-translational regulation of MITF-M expression and activity Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558991
displayName	Transcriptional and post-translational regulation of MITF-M expression and activity
eventOf	[Pathway:R-SSC-9730414] MITF-M-regulated melanocyte development - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-9824582] MAPK1 phosphorylates SOX10 - Sus scrofa [Reaction:R-SSC-9824999] GSK3B phosphorylates p-S73 MITF-M at residue S69 - Sus scrofa [Reaction:R-SSC-9824977] MAPK1-dependent phosphorylation of MITF-M - Sus scrofa [Reaction:R-SSC-9824979] XPO1 binds p-S69,73 MITF-M - Sus scrofa [BlackBoxEvent:R-SSC-9824986] XPO1-dependent export of p-S69,S73 MITF-M - Sus scrofa [Reaction:R-SSC-9926476] UBE2I sumoylates MITF-M - Sus scrofa [Reaction:R-SSC-9926478] MITF-M binds CREBBP,EP300 - Sus scrofa [Reaction:R-SSC-9926483] MARK3 phosphorylates MITF-M on S173 - Sus scrofa [Reaction:R-SSC-9824994] RPS6KA1-dependent phosphorylation of MITF-M - Sus scrofa [Reaction:R-SSC-9824995] GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405 - Sus scrofa [Reaction:R-SSC-9825704] AKT3 phosphorylates TBX3 - Sus scrofa [Reaction:R-SSC-9825759] MAPK-dependent phosphorylation of KARS - Sus scrofa [BlackBoxEvent:R-SSC-9825783] p-S207 KARS1 dimer translocates to the nucleus - Sus scrofa [Reaction:R-SSC-9825747] CREBBP acetylates HINT1 dimer - Sus scrofa [Reaction:R-SSC-9825772] SIRT1 deacetylates HINT1 dimer - Sus scrofa [Reaction:R-SSC-9825790] p-S207 KARS1 dimer synthesizes A(5')p4(5')A - Sus scrofa [Reaction:R-SSC-9825751] HINT1 binds MITF-M - Sus scrofa [Reaction:R-SSC-9825782] p-S207 KARS1 dimer binds MITF-M:HINT1 dimer - Sus scrofa [Reaction:R-SSC-9825788] p-S207 KARS displaces HINT1 - Sus scrofa
inferredFrom	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Transcriptional and post-translational regulation of MITF-M expression and activity
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9856649
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9730414] MITF-M-regulated melanocyte development
(inferredTo)	[Pathway:R-HSA-9856649] Transcriptional and post-translational regulation of MITF-M expression and activity

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