Reactome | MDK and PTN in ALK signaling

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MDK and PTN in ALK signaling Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556877
displayName	MDK and PTN in ALK signaling
eventOf	[Pathway:R-SSC-201556] Signaling by ALK - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-201486] ALK binds ligand pleiotrophin (PTN) - Sus scrofa [Reaction:R-SSC-9667914] ALK binds ligand midkine (MDK) - Sus scrofa [Reaction:R-SSC-9700200] PTPRZ dephosphorylates ligand-bound ALK dimers - Sus scrofa [Reaction:R-SSC-9700120] PTN and MDK bind to PTPRZ - Sus scrofa [Reaction:R-SSC-9700121] (PTN,MDK):PTPRZ oligomerizes - Sus scrofa
inferredFrom	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	MDK and PTN in ALK signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9851151
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-201556] Signaling by ALK
(inferredTo)	[Pathway:R-HSA-9851151] MDK and PTN in ALK signaling

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