Reactome | SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes

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SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes Show undefined attributes

catalystActivity	[CatalystActivity:10551666] histone H3 methyltransferase activity of ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10551668
displayName	SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes
eventOf	[Pathway:R-SSC-9843940] Regulation of endogenous retroelements by KRAB-ZFP proteins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9842833] SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes - Homo sapiens
input	6 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-SSC-9842840] ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes
output	6 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-SSC-9856770] ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin with H3K9me3 [nucleoplasm]
precedingEvent	[Reaction:R-SSC-9842839] ATF7IP:SETDB1 binds SUMO2-6K-TRIM28:KRAB-ZFP:retroelement chromatin - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9842833
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9843940] Regulation of endogenous retroelements by KRAB-ZFP proteins
(inferredTo)	[Reaction:R-HSA-9842833] SETDB1 in ATF7IP:SETDB1:SUMO2-6K-TRIM28:KRAB-ZFP:retroelement trimethylates lysine-9 of histone H3 in nucleosomes

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