Reactome | MAPKAPK2 phosphorylates RIPK1 at S320

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MAPKAPK2 phosphorylates RIPK1 at S320 Show undefined attributes

catalystActivity	[CatalystActivity:10477898] protein serine/threonine kinase activity of p-S272,T222,T334-MAPKAPK2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10550382
displayName	MAPKAPK2 phosphorylates RIPK1 at S320
eventOf	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-140935] TRAF2:TRADD:RIPK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAPKAPK2 phosphorylates RIPK1 at S320 MK2 phosphorylates RIPK1 at S320
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-9815499] TRAF2:TRADD:p-S320-RIPK1 [cytosol]
precedingEvent	[Reaction:R-SSC-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9815501
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-9815501] MAPKAPK2 phosphorylates RIPK1 at S320

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