Reactome | SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10549651] ubiquitin protein ligase activity of SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-SSC-9766645] CUL3:RBX1 ubiquitinates KEAP1 - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10549643
displayName	SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
hasComponent	[DefinedSet:R-SSC-9639292] SESN1,2 [cytosol] [Complex:R-SSC-9766542] ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-9766685] SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] - Homo sapiens
maxDepth	4
name	SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1
producedByEvent	[Reaction:R-SSC-9766687] SESN1,SESN1 bind SQSTM1 and KEAP1 - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-9766685
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-SSC-9766645] CUL3:RBX1 ubiquitinates KEAP1
(physicalEntity)	[CatalystActivity:10549651] ubiquitin protein ligase activity of SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]
(output)	[Reaction:R-SSC-9766687] SESN1,SESN1 bind SQSTM1 and KEAP1
(inferredTo)	[Complex:R-HSA-9766685] SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol]

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