Reactome | AKR1C1 hydrogenates PREDN,PREDL

Schema > Reaction > Entries

AKR1C1 hydrogenates PREDN,PREDL Show undefined attributes

catalystActivity	[CatalystActivity:10549346] steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of AKR1C1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10549348
displayName	AKR1C1 hydrogenates PREDN,PREDL
eventOf	[Pathway:R-SSC-9757110] Prednisone ADME - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites - Sus scrofa
inferredFrom	[Reaction:R-HSA-9758682] AKR1C1 hydrogenates PREDN,PREDL - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [DefinedSet:R-ALL-9759400] PREDN,PREDL (hepatocyte) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AKR1C1 hydrogenates PREDN,PREDL
output	[DefinedSet:R-ALL-9758681] 20H-PREDN,PREDL [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9758682
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9757110] Prednisone ADME
(precedingEvent)	[Reaction:R-SSC-9758661] UGT2B7,2B17,1A3 glucuronidates PRED metabolites
(inferredTo)	[Reaction:R-HSA-9758682] AKR1C1 hydrogenates PREDN,PREDL

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