Reactome | NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

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NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP Show undefined attributes

catalystActivity	[CatalystActivity:10549020] nucleoside diphosphate kinase activity of NME1:NME2 hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10549022
displayName	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP
eventOf	[Pathway:R-SSC-9748787] Azathioprine ADME - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9750555] NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP - Sus scrofa
goBiologicalProcess	[GO_BiologicalProcess:8764] xenobiotic metabolic process
inferredFrom	[Reaction:R-HSA-9748969] NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP - Homo sapiens
input	[SimpleEntity:R-ALL-9749033] 6TdGDP [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP 6TdGDP--DPK-->6TdGTP
output	[SimpleEntity:R-ALL-9749032] 6TdGTP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-SSC-9748963] GUK1 phosphorylates 6TdGMP to 6TdGDP - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9748969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9748787] Azathioprine ADME
(precedingEvent)	[Reaction:R-SSC-9750555] NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP
(inferredTo)	[Reaction:R-HSA-9748969] NME1:2 hexamer phosphorylates 6TdGDP to 6TdGTP

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