Reactome | Signaling by CSF3 (G-CSF)

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Signaling by CSF3 (G-CSF) Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558893
displayName	Signaling by CSF3 (G-CSF)
eventOf	[Pathway:R-SSC-1280215] Cytokine Signaling in Immune system - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-9677579] CSF3 dimer (GCSF dimer) binds CSF3R:JAK1:LYN - Sus scrofa [Reaction:R-SSC-9677585] CSF3 dimer:CSFR:LYN:JAK1 binds CSFR:LYN:JAK1 - Sus scrofa [Reaction:R-SSC-9674816] p-Y546,Y584-PTPN11 (in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:SHC:GRB2:PTPN11) dephosphorylates KRAS - Sus scrofa [Pathway:R-SSC-9705462] Inactivation of CSF3 (G-CSF) signaling - Sus scrofa
inferredFrom	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Signaling by CSF3 (G-CSF)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9674555
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1280215] Cytokine Signaling in Immune system
(inferredTo)	[Pathway:R-HSA-9674555] Signaling by CSF3 (G-CSF)

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