Reactome | PDGFRs bind type II TKI

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10546877
displayName	PDGFRs bind type II TKI
eventOf	[Pathway:R-SSC-186797] Signaling by PDGF - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9674095] PDGFRs bind type II TKI - Homo sapiens
input	[DefinedSet:R-SSC-186792] PDGFRA, PDGFRB [plasma membrane] [DefinedSet:R-ALL-9674079] type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PDGFRs bind type II TKI
output	[Complex:R-SSC-9674086] PDGFR:type II PDGFR-binding TKIs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9674095
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-186797] Signaling by PDGF
(inferredTo)	[Reaction:R-HSA-9674095] PDGFRs bind type II TKI

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