Reactome | Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

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Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10484516] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[BlackBoxEvent:R-SSC-927836] SMG6 hydrolyzes mRNA with premature termination codon - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10484503
displayName	Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-SSC-927856] phospho-UPF1 [cytosol] [Complex:R-SSC-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] [EntityWithAccessionedSequence:R-SSC-927867] SMG5 [cytosol] [EntityWithAccessionedSequence:R-SSC-927851] SMG6 [cytosol] [EntityWithAccessionedSequence:R-SSC-927838] SMG7 [cytosol] [Complex:R-SSC-927773] Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] [EntityWithAccessionedSequence:R-SSC-927801] UPF3A [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] - Homo sapiens
maxDepth	7
name	Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP
producedByEvent	[BlackBoxEvent:R-SSC-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-927854
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[BlackBoxEvent:R-SSC-927836] SMG6 hydrolyzes mRNA with premature termination codon
(physicalEntity)	[CatalystActivity:10484516] RNA endonuclease activity of Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
(output)	[BlackBoxEvent:R-SSC-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
(inferredTo)	[Complex:R-HSA-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

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