Reactome | PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

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PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 Show undefined attributes

catalystActivity	[CatalystActivity:10544485] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of PTGS2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10544487
displayName	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3
eventOf	[Pathway:R-SSC-9025094] Biosynthesis of DPAn-3 SPMs - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9026408] PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 - Homo sapiens
input	[SimpleEntity:R-ALL-9608444] DPAn-3 [cytosol] [SimpleEntity:R-ALL-1131953] hydrogen donor [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3 (7Z,10Z,13Z,16Z,19Z)-docosapentaenoate + AH2 + O2 => 13R-hydroxy-(7Z,10Z,14E,16Z,19Z)-docosapentaenoate + A + H2O
output	[SimpleEntity:R-ALL-9026407] 13(R)-HDPAn-3 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1130886] hydrogen acceptor [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9026408
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9025094] Biosynthesis of DPAn-3 SPMs
(inferredTo)	[Reaction:R-HSA-9026408] PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3

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