Reactome | TICAM1-dependent activation of IRF3/IRF7

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TICAM1-dependent activation of IRF3/IRF7 Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556501
displayName	TICAM1-dependent activation of IRF3/IRF7
eventOf	[Pathway:R-SSC-168164] Toll Like Receptor 3 (TLR3) Cascade - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221070] TRIF-dependent toll-like receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-168933] Dimerization of phosphorylated IRF3/IRF7 - Sus scrofa [Reaction:R-SSC-177671] Dimerized phospho-IRF3/IRF7 is transported to the nucleus - Sus scrofa
inferredFrom	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TICAM1-dependent activation of IRF3/IRF7 TLR3-mediated TICAM1-dependent activation of IRF3/IRF7 TLR3-mediated TRIF-dependent activation of IRF3/IRF7 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-9013973
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-168164] Toll Like Receptor 3 (TLR3) Cascade
(inferredTo)	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7

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