Reactome | IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1

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IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 Show undefined attributes

catalystActivity	[CatalystActivity:10542677] transmembrane receptor protein tyrosine kinase activity of IL24:IL22RA1:JAK1:IL20RB [plasma membrane]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10542679
displayName	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1
eventOf	[Pathway:R-SSC-8854691] Interleukin-20 family signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-8987063] IL24:IL22RA1:p-JAK1:IL20RB binds STAT3 - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-8987012] IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-448735] IL24:IL22RA1:JAK1:IL20RB [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1 JAK1 is phosphorylated by IL20,IL24:IL22RA1:JAK1:IL20RB receptor complex JAK1 is phosphorylated after il22r il20rb receptor interacts with il20 or il24 JAK1 is phosphorylated after IL20 or IL24 and IL22RA1:JAK1:IL20RB receptor complex interaction
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-8986999] IL24:IL22RA1:p-JAK1:IL20RB [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-448708] IL24 binds to IL22RA1:JAK1:IL20RB - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-8987012
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-8987063] IL24:IL22RA1:p-JAK1:IL20RB binds STAT3
(inferredTo)	[BlackBoxEvent:R-HSA-8987012] IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1

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