Reactome | IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5

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IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 Show undefined attributes

catalystActivity	[CatalystActivity:10542383] transmembrane receptor protein tyrosine kinase activity of IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10542385
displayName	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5
eventOf	[Pathway:R-SSC-8983432] Interleukin-15 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-8983374] p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-8983118] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 STAT3 is phosphorylated after IL15-IL15 receptor interaction
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-8983137] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-8983378] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-8983371
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8983432] Interleukin-15 signaling
(precedingEvent)	[BlackBoxEvent:R-SSC-8983374] p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5
(inferredTo)	[BlackBoxEvent:R-HSA-8983371] IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5

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