Reactome | CUL9:RBX1 ubiquitinates BIRC5

Schema > Reaction > Entries

CUL9:RBX1 ubiquitinates BIRC5 Show undefined attributes

catalystActivity	[CatalystActivity:10541621] ubiquitin protein ligase activity of NEDD8-CUL9:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10541635
displayName	CUL9:RBX1 ubiquitinates BIRC5
eventOf	[Pathway:R-SSC-8951664] Neddylation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18276] protein ubiquitination
inferredFrom	[Reaction:R-HSA-8956026] CUL9:RBX1 ubiquitinates BIRC5 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-50851] BIRC5 [cytosol] 3 × [DefinedSet:R-SSC-113595] Ub [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CUL9:RBX1 ubiquitinates BIRC5
output	[EntityWithAccessionedSequence:R-SSC-8955933] ub-BIRC5 [cytosol]
precedingEvent	[Reaction:R-SSC-8956025] AcM-UBE2M transfers NEDD8 to CUL9:RBX1 - Sus scrofa
regulatedBy	[NegativeRegulation:10541636] Negative regulation by 'NEDD8-CUL9:RBX1:CUL7:CCDC8:OBSL1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8956026
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8951664] Neddylation
(inferredTo)	[Reaction:R-HSA-8956026] CUL9:RBX1 ubiquitinates BIRC5

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