Reactome | Release of GABA at the synapse

Schema > Reaction > Entries

Release of GABA at the synapse Show undefined attributes

catalystActivity	[CatalystActivity:10483149] SNARE binding activity of Docked GABA loaded synaptic vesicle [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10483151
displayName	Release of GABA at the synapse
eventOf	[Pathway:R-SSC-888590] GABA synthesis, release, reuptake and degradation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-420688] GABAB heterodimeric receptor binds GABA - Sus scrofa
inferredFrom	[Reaction:R-HSA-888589] Release of GABA at the synapse - Homo sapiens
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [Complex:R-SSC-917774] Docked GABA loaded synaptic vesicle [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of GABA at the synapse
output	[EntityWithAccessionedSequence:R-SSC-210385] CPLX1 [cytosol] [EntityWithAccessionedSequence:R-SSC-936512] DNAJC5 [plasma membrane] [SimpleEntity:R-ALL-352003] GABA [extracellular region] [DefinedSet:R-SSC-210461-3] Homologues of RAB3A [plasma membrane] [EntityWithAccessionedSequence:R-SSC-936508] HSPA8 [plasma membrane] [DefinedSet:R-SSC-947479] PXLP-GAD dimers [plasma membrane] [EntityWithAccessionedSequence:R-SSC-210407] RIMS1 [cytosol] [EntityWithAccessionedSequence:R-SSC-917998] SLC32A1 [plasma membrane] [Complex:R-SSC-9670771] SNARE complex:Ca2+ [plasma membrane] [EntityWithAccessionedSequence:R-SSC-210514] STXBP1 [cytosol] [EntityWithAccessionedSequence:R-SSC-168786] SYT1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-917744] GABA loaded synaptic vesicle Docking and Priming - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-888589
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-888590] GABA synthesis, release, reuptake and degradation
(precedingEvent)	[Reaction:R-SSC-420688] GABAB heterodimeric receptor binds GABA
(inferredTo)	[Reaction:R-HSA-888589] Release of GABA at the synapse