Reactome | Formation of 4Fe-4S cluster on ISCA1:ISCA2

Schema > Reaction > Entries

Formation of 4Fe-4S cluster on ISCA1:ISCA2 Show undefined attributes

catalystActivity	[CatalystActivity:10537965] iron-sulfur transferase activity of ISCA1:ISCA2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10537967
displayName	Formation of 4Fe-4S cluster on ISCA1:ISCA2
eventOf	[Pathway:R-SSC-1362409] Mitochondrial iron-sulfur cluster biogenesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-9854984] Transfer of Fe-S clusters to SDHB - Sus scrofa
inferredFrom	[Reaction:R-HSA-8878815] Formation of 4Fe-4S cluster on ISCA1:ISCA2 - Homo sapiens
input	2 × [Complex:R-SSC-8878793] GLRX5:2Fe-2S [mitochondrial matrix] [Complex:R-SSC-8878840] ISCA1:ISCA2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	Formation of 4Fe-4S cluster on ISCA1:ISCA2
output	2 × [EntityWithAccessionedSequence:R-SSC-2564761] GLRX5 [mitochondrial matrix] [Complex:R-SSC-8878796] ISCA1:ISCA2:4Fe-4S [mitochondrial matrix]
regulatedBy	[Requirement:10537968] Requirement by 'HSCB [mitochondrial matrix]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8878815
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1362409] Mitochondrial iron-sulfur cluster biogenesis
(precedingEvent)	[BlackBoxEvent:R-SSC-9854984] Transfer of Fe-S clusters to SDHB
(inferredTo)	[Reaction:R-HSA-8878815] Formation of 4Fe-4S cluster on ISCA1:ISCA2

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