Reactome | SETD6 methylates RELA in the NFkB complex

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SETD6 methylates RELA in the NFkB complex Show undefined attributes

catalystActivity	[CatalystActivity:10535556] protein-lysine N-methyltransferase activity of SETD6 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10535558
displayName	SETD6 methylates RELA in the NFkB complex
eventOf	[Pathway:R-SSC-3214841] PKMTs methylate histone lysines - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8865237] SETD6 methylates RELA in the NFkB complex - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-SSC-177673] NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SETD6 methylates RELA in the NFkB complex
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-SSC-8865239] NFkB Complex with MeK310-RELA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8865237
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-3214841] PKMTs methylate histone lysines
(inferredTo)	[Reaction:R-HSA-8865237] SETD6 methylates RELA in the NFkB complex

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