Reactome | NTPDase8 hydrolyzes nucleoside triphosphates

Schema > Reaction > Entries

NTPDase8 hydrolyzes nucleoside triphosphates Show undefined attributes

catalystActivity	[CatalystActivity:10533649] ribonucleoside triphosphate phosphatase activity of NTPDase8:Ca2+,Mg2+ [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10533651
displayName	NTPDase8 hydrolyzes nucleoside triphosphates
eventOf	[Pathway:R-SSC-8850843] Phosphate bond hydrolysis by NTPDase proteins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-8851550] NTPDase8 hydrolyzes nucleoside diphosphates - Sus scrofa
inferredFrom	[Reaction:R-HSA-8851538] NTPDase8 hydrolyzes nucleoside triphosphates - Homo sapiens
input	[DefinedSet:R-ALL-9726184] ATP,GTP,ITP,CTP,TTP,UTP [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	NTPDase8 hydrolyzes nucleoside triphosphates ATP + H2O => ADP + phosphate + H(+) GTP + H2O => GDP + phosphate + H(+) ITP + H2O => IDP + phosphate + H(+) CTP + H2O => CDP + phosphate + H(+) dTTP + H2O => dTDP + phosphate + H(+) UTP + H2O => UDP + phosphate + H(+)
output	[DefinedSet:R-ALL-9726189] ADP,GDP,IDP,CDP,TDP,UDP [extracellular region] [SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-109277] Pi [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-8851538
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-8850843] Phosphate bond hydrolysis by NTPDase proteins
(precedingEvent)	[Reaction:R-SSC-8851550] NTPDase8 hydrolyzes nucleoside diphosphates
(inferredTo)	[Reaction:R-HSA-8851538] NTPDase8 hydrolyzes nucleoside triphosphates

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