Reactome | trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA

Schema > Reaction > Entries

trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10448913] enoyl-CoA hydratase activity of ECHS1 hexamer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10453275
displayName	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA
eventOf	[Pathway:R-SSC-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H - Sus scrofa
inferredFrom	[Reaction:R-HSA-77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-77324] trans-Hex-2-enoyl-CoA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA (2E)-hexenoyl-CoA + H2O => (3S)-hydroxyhexanoyl-CoA
output	[SimpleEntity:R-ALL-77322] (S)-Hydroxyhexanoyl-CoA [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-77327] Hexanoyl-CoA+FAD => trans-Hex-2-enoyl-CoA+FADH2 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-77325
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-77350] Beta oxidation of hexanoyl-CoA to butanoyl-CoA
(precedingEvent)	[Reaction:R-SSC-77323] (S)-Hydroxyhexanoyl-CoA+NAD => 3-Oxohexanoyl-CoA+NADH+H
(inferredTo)	[Reaction:R-HSA-77325] trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA

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