Reactome | Death Receptor Signaling

Schema > Pathway > Entries

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10555717
displayName	Death Receptor Signaling
eventOf	[TopLevelPathway:R-SSC-162582] Signal Transduction - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:140] cell surface receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-SSC-75157] FasL/ CD95L signaling - Sus scrofa [Pathway:R-SSC-75893] TNF signaling - Sus scrofa [Pathway:R-SSC-75158] TRAIL signaling - Sus scrofa [Pathway:R-SSC-193704] p75 NTR receptor-mediated signalling - Sus scrofa
inferredFrom	[Pathway:R-HSA-73887] Death Receptor Signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	Death Receptor Signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-73887
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[TopLevelPathway:R-SSC-162582] Signal Transduction
(inferredTo)	[Pathway:R-HSA-73887] Death Receptor Signaling
(hasEncapsulatedEvent)	[Pathway:R-SSC-140534] Caspase activation via Death Receptors in the presence of ligand

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