Reactome | conversion of dUMP to dTMP

Schema > Reaction > Entries

conversion of dUMP to dTMP Show undefined attributes

catalystActivity	[CatalystActivity:10450685] thymidylate synthase activity of TS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10450687
displayName	conversion of dUMP to dTMP
eventOf	[Pathway:R-SSC-499943] Interconversion of nucleotide di- and triphosphates - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] - Sus scrofa
inferredFrom	[Reaction:R-HSA-73605] conversion of dUMP to dTMP - Homo sapiens
input	[SimpleEntity:R-ALL-1132205] 5,10-methylenetetrahydrofolate(2-) [cytosol] [SimpleEntity:R-ALL-109382] dUMP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	conversion of dUMP to dTMP dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate => 7,8-dihydrofolate + dTMP
output	[SimpleEntity:R-ALL-73604] DHF [cytosol] [SimpleEntity:R-ALL-109366] TMP [cytosol]
precedingEvent	[Reaction:R-SSC-73596] dCMP + H2O => dUMP + NH4+ - Sus scrofa [Reaction:R-SSC-73666] hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-73605
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-499943] Interconversion of nucleotide di- and triphosphates
(precedingEvent)	[Reaction:R-SSC-73635] dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
(inferredTo)	[Reaction:R-HSA-73605] conversion of dUMP to dTMP

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