Reactome | PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

Schema > Reaction > Entries

PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate Show undefined attributes

catalystActivity	[CatalystActivity:10449336] 6-phosphogluconolactonase activity of PGLS [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10449338
displayName	PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate
eventOf	[Pathway:R-SSC-71336] Pentose phosphate pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-71299] PGD decarboxylates 6-phospho-D-gluconate - Sus scrofa
inferredFrom	[Reaction:R-HSA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-31467] D-Glucono-1,5-lactone 6-phosphate [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29996] PDG [cytosol]
precedingEvent	[Reaction:R-SSC-70377] G6PD multimers dehydrogenate G6P - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-71296
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-71336] Pentose phosphate pathway
(precedingEvent)	[Reaction:R-SSC-71299] PGD decarboxylates 6-phospho-D-gluconate
(inferredTo)	[Reaction:R-HSA-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate

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