Reactome | Enolase dimers (ENO1,2,3) convert PEP to 2PG

Schema > Reaction > Entries

Enolase dimers (ENO1,2,3) convert PEP to 2PG Show undefined attributes

catalystActivity	[CatalystActivity:10448587] phosphopyruvate hydratase activity of enolase dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448589
displayName	Enolase dimers (ENO1,2,3) convert PEP to 2PG
eventOf	[Pathway:R-SSC-70263] Gluconeogenesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-71445] PGAM dimers isomerise 2PG to 3PG - Sus scrofa
inferredFrom	[Reaction:R-HSA-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Enolase dimers (ENO1,2,3) convert PEP to 2PG H2O + phosphoenolpyruvate => (2R)-2-phosphoglycerate
output	[SimpleEntity:R-ALL-30485] 2PG [cytosol]
precedingEvent	[Reaction:R-SSC-372449] SLC25A1 may exchange mitochondrial PEP for cytosolic anion - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70494
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-SSC-71445] PGAM dimers isomerise 2PG to 3PG
(inferredTo)	[Reaction:R-HSA-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG

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