Reactome | GAPDH tetramers reduce 1,3BPG to GA3P

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GAPDH tetramers reduce 1,3BPG to GA3P Show undefined attributes

catalystActivity	[CatalystActivity:10448469] glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity of GAPDH tetramers [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448539
displayName	GAPDH tetramers reduce 1,3BPG to GA3P
eventOf	[Pathway:R-SSC-70263] Gluconeogenesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-70481] TPI1 dimer isomerizes GA3P to DHAP - Sus scrofa [Reaction:R-SSC-71495] Aldolase tetramers convert GA3P and DHAP to F1,6PP - Sus scrofa
inferredFrom	[Reaction:R-HSA-70482] GAPDH tetramers reduce 1,3BPG to GA3P - Homo sapiens
input	[SimpleEntity:R-ALL-29800] 1,3BPG [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GAPDH tetramers reduce 1,3BPG to GA3P (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH => D-glyceraldehyde 3-phosphate + NAD(+) + phosphate
output	[SimpleEntity:R-ALL-29578] GA3P [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-SSC-70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70482
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-SSC-70481] TPI1 dimer isomerizes GA3P to DHAP [Reaction:R-SSC-71495] Aldolase tetramers convert GA3P and DHAP to F1,6PP
(inferredTo)	[Reaction:R-HSA-70482] GAPDH tetramers reduce 1,3BPG to GA3P

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