Reactome | GPI dimer isomerizes Fru(6)P to G6P

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GPI dimer isomerizes Fru(6)P to G6P Show undefined attributes

catalystActivity	[CatalystActivity:10448512] glucose-6-phosphate isomerase activity of GPI dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10448516
displayName	GPI dimer isomerizes Fru(6)P to G6P
eventOf	[Pathway:R-SSC-5628897] TP53 Regulates Metabolic Genes - Sus scrofa [Pathway:R-SSC-70263] Gluconeogenesis - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Sus scrofa [Reaction:R-SSC-70377] G6PD multimers dehydrogenate G6P - Sus scrofa [Reaction:R-SSC-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP - Sus scrofa
inferredFrom	[Reaction:R-HSA-70475] GPI dimer isomerizes Fru(6)P to G6P - Homo sapiens
input	[SimpleEntity:R-ALL-29512] Fru(6)P [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GPI dimer isomerizes Fru(6)P to G6P beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate
output	[SimpleEntity:R-ALL-30537] G6P [cytosol]
precedingEvent	[Reaction:R-SSC-70479] FBP tetramers hydrolyze F1,6PP to Fru(6)P - Sus scrofa [Reaction:R-SSC-5628905] TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-70475
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5628897] TP53 Regulates Metabolic Genes [Pathway:R-SSC-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-SSC-198513] SLC7A4 exchanges G6P for Pi across the ER membrane [Reaction:R-SSC-70377] G6PD multimers dehydrogenate G6P [Reaction:R-SSC-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP
(inferredTo)	[Reaction:R-HSA-70475] GPI dimer isomerizes Fru(6)P to G6P

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