Reactome | Cyclin A:Cdk2-associated events at S phase entry

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Cyclin A:Cdk2-associated events at S phase entry Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10556559
displayName	Cyclin A:Cdk2-associated events at S phase entry
eventOf	[Pathway:R-SSC-69242] S Phase - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24606] positive regulation of DNA replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-174054] Formation of Cyclin A:Cdk2 complexes - Sus scrofa [Reaction:R-SSC-174273] Translocation of Cyclin A:Cdk2 complexes to the nucleus - Sus scrofa [Reaction:R-SSC-187828] Translocation of p21 to the nucleus - Sus scrofa [Reaction:R-SSC-187506] Translocation of p27 to the nucleoplasm - Sus scrofa [Pathway:R-SSC-187577] SCF(Skp2)-mediated degradation of p27/p21 - Sus scrofa [Reaction:R-SSC-174164] Phosphorylation of Cyclin A:Cdk2 at Tyr 15 - Sus scrofa [Reaction:R-SSC-174110] Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2 - Sus scrofa [Reaction:R-SSC-187949] CAK-mediated phosphorylation of Cyclin A:Cdk2 - Sus scrofa [Reaction:R-SSC-187916] Cyclin A:Cdk2 mediated phosphorylation of p27/p21 - Sus scrofa [Reaction:R-SSC-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Sus scrofa [Reaction:R-SSC-187948] Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2 - Sus scrofa
inferredFrom	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cyclin A:Cdk2-associated events at S phase entry
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-69656
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-69242] S Phase
(inferredTo)	[Pathway:R-HSA-69656] Cyclin A:Cdk2-associated events at S phase entry

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