Reactome | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

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Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Show undefined attributes

created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10558507
displayName	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
eventOf	[Pathway:R-SSC-390466] Chaperonin-mediated protein folding - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-SSC-6814119] TRiC/CCT binds unfolded G-protein beta subunit - Sus scrofa [Reaction:R-SSC-6814124] ATP binds G-protein beta associated TRiC/CCT - Sus scrofa [Reaction:R-SSC-6814120] ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT - Sus scrofa [Reaction:R-SSC-6814409] CK2 phosphorylates PDCL - Sus scrofa [Reaction:R-SSC-6814121] PDCL binds G-protein beta and TRiC/CCT - Sus scrofa [Reaction:R-SSC-8850527] PDCL releases folded G-beta from TRiC/CCT - Sus scrofa [Reaction:R-SSC-6814418] PDCL promotes formation of G-beta:G-gamma heterodimers - Sus scrofa [Reaction:R-SSC-8850560] G-protein alpha releases G-protein heterotrimer from PDCL - Sus scrofa [Reaction:R-SSC-8850534] PDCL promotes G-protein beta 5 folding - Sus scrofa [Reaction:R-SSC-8850529] RGS proteins bind GNB5 and CCT/TRiC - Sus scrofa [Reaction:R-SSC-8850539] Release of GNB5:RGS dimers from CCT/TRiC - Sus scrofa
inferredFrom	[Pathway:R-HSA-6814122] Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-6814122
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-390466] Chaperonin-mediated protein folding
(inferredTo)	[Pathway:R-HSA-6814122] Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

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