Reactome | EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA

Schema > Reaction > Entries

EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA Show undefined attributes

catalystActivity	[CatalystActivity:10530992] (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity of EHHADH [peroxisomal matrix]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10530994
displayName	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA
eventOf	[Pathway:R-SSC-390247] Beta-oxidation of very long chain fatty acids - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA - Sus scrofa [Reaction:R-SSC-9856871] MDH1 reduces OA - Sus scrofa
inferredFrom	[Reaction:R-HSA-6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-390248] 3-hydroxyhexacosanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-192307] NAD+ [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA 3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+ (EHHADH)
output	[SimpleEntity:R-ALL-390241] 3-ketohexacosanoyl-CoA [peroxisomal matrix] [SimpleEntity:R-ALL-193465] H+ [peroxisomal matrix] [SimpleEntity:R-ALL-192305] NADH [peroxisomal matrix]
precedingEvent	[Reaction:R-SSC-6809263] EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-6809264
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-390247] Beta-oxidation of very long chain fatty acids
(precedingEvent)	[Reaction:R-SSC-390250] 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA [Reaction:R-SSC-9856871] MDH1 reduces OA
(inferredTo)	[Reaction:R-HSA-6809264] EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA

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