Reactome | 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

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12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10525241
displayName	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
eventOf	[Pathway:R-SSC-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Homo sapiens
input	[Complex:R-SSC-6791568] 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
output	[Complex:R-SSC-72499] 60S ribosomal complex [cytosol]
precedingEvent	[BlackBoxEvent:R-SSC-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Sus scrofa
regulatedBy	[Requirement:10525242] Requirement by 'C1D [nucleoplasm]' [Requirement:10525243] Requirement by 'SKIV2L2 [nucleoplasm]' [Requirement:10525244] Requirement by 'DIS3 [nucleoplasm]' [Requirement:10525245] Requirement by 'MPHOSPH6 [nucleoplasm]' [Requirement:10525246] Requirement by 'EXOSC10 [nucleoplasm]' [Requirement:10525247] Requirement by 'ERI1 [nucleoplasm]' [Requirement:10525248] Requirement by 'ISG20L2 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-6791218
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6791226] Major pathway of rRNA processing in the nucleolus and cytosol
(inferredTo)	[BlackBoxEvent:R-HSA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

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