Reactome | IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated

Schema > BlackBoxEvent > Entries

IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated Show undefined attributes

catalystActivity	[CatalystActivity:10524776] non-membrane spanning protein tyrosine kinase activity of IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10524778
displayName	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
eventOf	[Pathway:R-SSC-6785807] Interleukin-4 and Interleukin-13 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-6786124] STAT3,STAT6 bind p-Y-IL4R - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-6786090] IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-6786061] IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-6786058] JAK1 binds IL4R in IL4-bound IL4R1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-6786096
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6785807] Interleukin-4 and Interleukin-13 signaling
(precedingEvent)	[Reaction:R-SSC-6786124] STAT3,STAT6 bind p-Y-IL4R
(inferredTo)	[BlackBoxEvent:R-HSA-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated

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