Reactome | RNA Pol II initiates transcription from damaged DNA template

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RNA Pol II initiates transcription from damaged DNA template Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10523886
displayName	RNA Pol II initiates transcription from damaged DNA template
eventOf	[Pathway:R-SSC-6781823] Formation of TC-NER Pre-Incision Complex - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template - Sus scrofa
inferredFrom	[BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template - Homo sapiens
input	[OtherEntity:R-ALL-5688114] Distorted dsDNA [nucleoplasm] [Complex:R-SSC-113401] RNA Polymerase II holoenzyme complex (unphosphorylated) [nucleoplasm] [Complex:R-SSC-109634] TFIIH [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNA Pol II initiates transcription from damaged DNA template
output	[Complex:R-SSC-6781821] Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49633] Sus scrofa
stId	R-SSC-6781818
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6781823] Formation of TC-NER Pre-Incision Complex
(precedingEvent)	[BlackBoxEvent:R-SSC-6781824] Active RNA Pol II complex transcribes lesion-containing DNA template
(inferredTo)	[BlackBoxEvent:R-HSA-6781818] RNA Pol II initiates transcription from damaged DNA template

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