Reactome | PXLP-K754-GLDC dimer decarboxylates Gly

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PXLP-K754-GLDC dimer decarboxylates Gly Show undefined attributes

catalystActivity	[CatalystActivity:10522437] glycine dehydrogenase (decarboxylating) activity of PXLP-K754-GLDC dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10522439
displayName	PXLP-K754-GLDC dimer decarboxylates Gly
eventOf	[Pathway:R-SSC-6783984] Glycine degradation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF - Sus scrofa
inferredFrom	[Reaction:R-HSA-5693967] PXLP-K754-GLDC dimer decarboxylates Gly - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-6793611] GCSH [mitochondrial matrix] [SimpleEntity:R-ALL-159549] Gly [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PXLP-K754-GLDC dimer decarboxylates Gly glycine + H(+) + N(6)-((R)-lipoyl)-L-lysyl-(glycine-cleavage complex H protein) => CO2 + N(6)-((R)-S(8)-aminomethyldihydrolipoyl)-L-lysyl-(glycine-cleavage complex H protein)
output	[Complex:R-SSC-5693969] AmMeLipoGCSH:SAMDLL [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-5694018] DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate - Sus scrofa [Reaction:R-SSC-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5693967
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-6783984] Glycine degradation
(inferredTo)	[Reaction:R-HSA-5693967] PXLP-K754-GLDC dimer decarboxylates Gly
(precedingEvent)	[Reaction:R-SSC-5693977] AMT transfers NH2CH2 from GCSH:SAMDLL to THF

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