Reactome | LC3 is cleaved by ATG4

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10519295] cysteine-type endopeptidase activity of ATG4 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10519297
displayName	LC3 is cleaved by ATG4
eventOf	[Pathway:R-SSC-1632852] Macroautophagy - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-SSC-5682011] LC3 binds ATG7 dimer - Sus scrofa
inferredFrom	[Reaction:R-HSA-5681987] LC3 is cleaved by ATG4 - Homo sapiens
input	[DefinedSet:R-SSC-5682661] LC3 family precursors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	LC3 is cleaved by ATG4
output	[DefinedSet:R-SSC-5682694] LC3 family [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5681987
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-1632852] Macroautophagy
(precedingEvent)	[BlackBoxEvent:R-SSC-5682011] LC3 binds ATG7 dimer
(inferredTo)	[Reaction:R-HSA-5681987] LC3 is cleaved by ATG4

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