Reactome | ATG16L1 complex transfers LC3 from ATG3 to PE

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ATG16L1 complex transfers LC3 from ATG3 to PE Show undefined attributes

catalystActivity	[CatalystActivity:10519192] ubiquitin-like protein transferase activity of ATG16L1 complex:WIPI2:PI(3,5)P2 [phagophore assembly site membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:5679192] phagophore assembly site membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10519194
displayName	ATG16L1 complex transfers LC3 from ATG3 to PE
eventOf	[Pathway:R-SSC-1632852] Macroautophagy - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5682377] LC3 de-lipidation by ATG4 - Sus scrofa [Reaction:R-SSC-5682896] LC3:ATG7 dimer binds ATG3 - Sus scrofa [BlackBoxEvent:R-SSC-5682388] Autophagosome maturation - Sus scrofa
inferredFrom	[Reaction:R-HSA-5678490] ATG16L1 complex transfers LC3 from ATG3 to PE - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-9819371] ATG3 [cytosol] [SimpleEntity:R-ALL-5681998] PE [phagophore assembly site membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ATG16L1 complex transfers LC3 from ATG3 to PE
output	[EntityWithAccessionedSequence:R-SSC-5671860] ATG3 [cytosol] [Complex:R-SSC-5682873] LC3:PE [phagophore assembly site membrane]
precedingEvent	[Reaction:R-SSC-5683593] ATG7:ATG3:LC3 dissociates - Sus scrofa [Reaction:R-SSC-5679255] WIPI2 binds ATG12:ATG5:ATG16L - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5678490
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1632852] Macroautophagy
(precedingEvent)	[BlackBoxEvent:R-SSC-5682388] Autophagosome maturation [Reaction:R-SSC-5682377] LC3 de-lipidation by ATG4 [Reaction:R-SSC-5682896] LC3:ATG7 dimer binds ATG3
(inferredTo)	[Reaction:R-HSA-5678490] ATG16L1 complex transfers LC3 from ATG3 to PE