Reactome | RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers

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RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10518676
displayName	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
eventOf	[Pathway:R-SSC-5673000] RAF activation - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9653108] Raf dimer inhibitors bind RAF heterodimers - Sus scrofa [Reaction:R-SSC-5672969] Phosphorylation of RAF - Sus scrofa
inferredFrom	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers - Homo sapiens
input	[DefinedSet:R-SSC-5672731] dephosphorylated "receiver" RAF/KSR1 [cytosol] [Complex:R-SSC-5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
output	[Complex:R-SSC-5672733] p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane]
precedingEvent	[Reaction:R-SSC-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Sus scrofa [Reaction:R-SSC-5672958] YWHAB dimer dissociates from KSR1:MARK3 - Sus scrofa
regulatedBy	[NegativeRegulation:10518677] Negative regulation by 'BRAP:KSR1:MARK3 [cytosol]' [PositiveRegulation:10518678] Positive regulation by 'MAP3K11 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5672966
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5673000] RAF activation
(precedingEvent)	[Reaction:R-SSC-9653108] Raf dimer inhibitors bind RAF heterodimers [Reaction:R-SSC-5672969] Phosphorylation of RAF
(inferredTo)	[Reaction:R-HSA-5672966] RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers

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