Reactome | TNFA binds TNFR2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10517991
displayName	TNFA binds TNFR2
eventOf	[Pathway:R-SSC-5668541] TNFR2 non-canonical NF-kB pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5668467] 2xTNFR2 binds TNFA trimer:TNFR2 - Sus scrofa
inferredFrom	[Reaction:R-HSA-5668404] TNFA binds TNFR2 - Homo sapiens
input	[Complex:R-SSC-3371351] TNF(1-233) trimer [plasma membrane] [EntityWithAccessionedSequence:R-SSC-5661484] TNFRSF1B [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TNFA binds TNFR2
output	[Complex:R-SSC-5668502] TNFA trimer:TNFR2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5668404
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[Reaction:R-SSC-5668467] 2xTNFR2 binds TNFA trimer:TNFR2
(inferredTo)	[Reaction:R-HSA-5668404] TNFA binds TNFR2