Reactome | Profilin:G-actin binds MKL1

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10517906
displayName	Profilin:G-actin binds MKL1
eventOf	[Pathway:R-SSC-5663220] RHO GTPases Activate Formins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 - Sus scrofa
inferredFrom	[Reaction:R-HSA-5666001] Profilin:G-actin binds MKL1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-5665975] MRTFA [cytosol] [Complex:R-SSC-203080] Profilin:G-actin [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Profilin:G-actin binds MKL1
output	[Complex:R-SSC-5665995] Profilin:G-actin:MKL1 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5666001
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-SSC-5663220] RHO GTPases Activate Formins
(precedingEvent)	[Reaction:R-SSC-5665982] RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
(inferredTo)	[Reaction:R-HSA-5666001] Profilin:G-actin binds MKL1

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