Reactome | POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA

Schema > Reaction > Entries

POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10517465
displayName	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA
eventOf	[Pathway:R-SSC-5656121] Translesion synthesis by POLI - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5656148] POLI incorporates dNMP opposite to damaged DNA base - Sus scrofa
inferredFrom	[Reaction:R-HSA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA - Homo sapiens
input	[Complex:R-SSC-5656114] MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] [Complex:R-SSC-5656093] POLI:Mg2+ [nucleoplasm] [Complex:R-SSC-110279] POLZ [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-3006726] REV1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA
output	[Complex:R-SSC-5656097] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm]
precedingEvent	[Reaction:R-SSC-5652009] RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5656105
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5656121] Translesion synthesis by POLI
(precedingEvent)	[Reaction:R-SSC-5656148] POLI incorporates dNMP opposite to damaged DNA base
(inferredTo)	[Reaction:R-HSA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA

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