Reactome | SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

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SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) Show undefined attributes

catalystActivity	[CatalystActivity:10514145] histone H4 methyltransferase activity of SETD8 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10514147
displayName	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)
eventOf	[Pathway:R-SSC-3214841] PKMTs methylate histone lysines - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) - Homo sapiens
input	[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-181902] HIST1H4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20) SETD8 methylates lysine-21 of histone H4
output	[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-5423110] MeK21-HIST1H4 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5423038
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-3214841] PKMTs methylate histone lysines
(inferredTo)	[Reaction:R-HSA-5423038] SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)

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