Reactome | CLIP3 and CYLD bind TNF signaling complex

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CLIP3 and CYLD bind TNF signaling complex Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10513319
displayName	CLIP3 and CYLD bind TNF signaling complex
eventOf	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5357928] CLIP3 and CYLD bind TNF signaling complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-5212669] CLIP3 [cytosol] [EntityWithAccessionedSequence:R-SSC-741420] CYLD [cytosol] [Complex:R-SSC-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	CLIP3 and CYLD bind TNF signaling complex
output	[Complex:R-SSC-5357950] CYLD:CLIP3:TNF:TNFR1:TRADD:K63pUb-RIP1:TRAF2:BIRC2/3 [plasma membrane]
precedingEvent	[BlackBoxEvent:R-SSC-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5357928
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-5357905] Regulation of TNFR1 signaling
(inferredTo)	[Reaction:R-HSA-5357928] CLIP3 and CYLD bind TNF signaling complex

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