Reactome | p-AXL binds PI3K

Schema > Reaction > Entries

p-AXL binds PI3K Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10513245
displayName	p-AXL binds PI3K
eventOf	[Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 - Sus scrofa
inferredFrom	[Reaction:R-HSA-5357479] p-AXL binds PI3K - Homo sapiens
input	[Complex:R-SSC-74693] PI3K [cytosol] [Complex:R-SSC-5357462] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-AXL binds PI3K
output	[Complex:R-SSC-5357453] VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane]
precedingEvent	[Reaction:R-SSC-5357429] AXL autophosphorylates on Y779 and Y821 - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-5357479
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-4420097] VEGFA-VEGFR2 Pathway
(precedingEvent)	[Reaction:R-SSC-5218819] VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
(inferredTo)	[Reaction:R-HSA-5357479] p-AXL binds PI3K