Reactome | Interleukin-3, Interleukin-5 and GM-CSF signaling

Schema > Pathway > Entries

Interleukin-3, Interleukin-5 and GM-CSF signaling Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10557489
displayName	Interleukin-3, Interleukin-5 and GM-CSF signaling
eventOf	[Pathway:R-SSC-449147] Signaling by Interleukins - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:8651] cytokine-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-SSC-913360] GM-CSF receptor alpha subunit binds GM-CSF - Sus scrofa [Reaction:R-SSC-913371] GM-CSF receptor alpha:GM-CSF binds Bc - Sus scrofa [Reaction:R-SSC-913446] Interleukin-5 is a homodimer - Sus scrofa [Reaction:R-SSC-913456] Interleukin-5 receptor alpha subunit binds Interleukin-5 - Sus scrofa [Reaction:R-SSC-913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 - Sus scrofa [BlackBoxEvent:R-SSC-879942] The receptor is activated - Sus scrofa [Reaction:R-SSC-879910] JAK2 is phosphorylated, activated - Sus scrofa [Reaction:R-SSC-879930] STAT5 is recruited by JAK2 - Sus scrofa [Reaction:R-SSC-879909] Activation of STAT5a/b by JAK2 - Sus scrofa [Reaction:R-SSC-921155] p-STAT5 dissociates from the receptor complex - Sus scrofa [Reaction:R-SSC-879907] Tyrosine kinases phosphorylate the receptor - Sus scrofa [Reaction:R-SSC-879934] Recruitment of SHC1 is mediated by Y593 of the common beta chain - Sus scrofa [Pathway:R-SSC-912526] Interleukin receptor SHC signaling - Sus scrofa [Pathway:R-SSC-912631] Regulation of signaling by CBL - Sus scrofa [Reaction:R-SSC-879914] IL3 stimulation induces Vav binding to Tec kinase - Sus scrofa [Reaction:R-SSC-909738] SHP1 and SHP2 bind the common beta chain - Sus scrofa [Reaction:R-SSC-914036] SHP1 and SHP2 dephosphorylate Y628 of IL3RB - Sus scrofa [Reaction:R-SSC-913451] IL3RB is phosphorylated on Ser-585 - Sus scrofa [Reaction:R-SSC-914182] 14-3-3 zeta binding allows recruitment of PI3K - Sus scrofa
inferredFrom	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Interleukin-3, Interleukin-5 and GM-CSF signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49633] Sus scrofa
stId	R-SSC-512988
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-449147] Signaling by Interleukins
(hasEncapsulatedEvent)	[Pathway:R-SSC-5673001] RAF/MAP kinase cascade
(inferredTo)	[Pathway:R-HSA-512988] Interleukin-3, Interleukin-5 and GM-CSF signaling

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